Referring audio-visual segmentation (RAVS) has recently seen significant advancements, yet challenges remain in integrating multimodal information as well as deeply understanding and reasoning about audiovisual content. To extend the boundaries of RAVS and facilitate future research in this field, we propose Omnimodal Referring Audio-Visual Segmentation (OmniAVS), a new dataset containing 2,098 videos and 59,458 multimodal referring expressions. OmniAVS stands out with three key innovations: (1) 8 types of multimodal expressions that flexibly combine text, speech, sound, and visual cues; (2) an emphasis on understanding audio content beyond just detecting their presence; and (3) the inclusion of complex reasoning and world knowledge in expressions. Furthermore, we introduce Omnimodal Instructed Segmentation Assistant (OISA), to address the challenges of multimodal reasoning and fine-grained understanding of audiovisual content in OmniAVS. OISA uses MLLM to comprehend complex cues and perform reasoning-based segmentation. Extensive experiments on 10 datasets show that OISA outperforms existing methods on OmniAVS and achieves competitive results on other related tasks.