Panoptic Scene Graph Generation (PSG) integrates instance segmentation with relation understanding to capture pixel-level structural relationships in complex scenes. Although recent approaches leveraging pre-trained vision-language models (VLMs) have significantly improved performance in the open-vocabulary setting, they commonly ignore the inherent limitations of VLMs in spatial relation reasoning, such as difficulty in distinguishing object relative positions, which results in suboptimal relation prediction.Motivated by the denoising diffusion model's inversion process in preserving the spatial structure of input images, we propose SPADE (SPatial-Aware Denoising-nEtwork) framework---a novel approach for open-vocabulary PSG. SPADE consists of two key steps: (1) inversion-guided calibration for the UNet adaption, and (2) spatial-aware context reasoning. In the first step, we calibrate a general pre-trained teacher diffusion model into a PSG-specific denoising network with cross-attention maps derived during inversion through a lightweight LoRA-based fine-tuning strategy. In the second step, we develop a spatial-aware relation graph transformer that captures both local and long-range contextual information, facilitating the generation of high-quality relation queries. Extensive experiments on benchmark PSG and Visual Genome datasets demonstrate that SPADE outperforms state-of-the-art methods in both closed-set and open-set scenarios, particularly excelling in spatial relationship prediction. The code is available at: https://anonymous.4open.science/r/SPADE-105F.