The 2nd Workshop and Challenge on Unlearning and Model Editing (U&ME) is a half-day event at ICCV 2025 in Hawaii on October 19, 2025, in the afternoon, and focuses on the growing need for new, efficient, and effective techniques for editing trained models, especially large generative models. Such models have practically unlimited functionality in the output they can generate. To provide this functionality, generative models require massive amounts of data and enormous compute costs to train, making it prohibitively expensive to retrain them whenever the need arises: when safety risks are uncovered, when deploying them to compute or storage-restricted platforms, or simply due to changing requirements. In particular, ensuring these models are safe and compliant with regulations can be difficult due to their broad range of capabilities and a continuously evolving regulatory landscape.